Patients should be instructed not to bite the mouth piece. Treatment with Seretide should not be stopped abruptly due to risk of exacerbation. 3. As Seretide contains salmeterol and fluticasone propionate, the type and severity of adverse reactions associated with each of the compounds may be expected. The safety of long-term treatment with salmeterol-FP metered dose inhaler (25/50 micrograms, 1 or 2 inhalations twice daily) was evaluated in a 16-week, open-label, extension treatment period. 7. Salmeterol, a long acting beta2 adrenergic receptor agonist, is used in the treatment of following conditions: Control and prevention of asthma; Bronco spasm ( wheezing, cough, shortness of breath) It will relieve symptoms such as tightness in your chest, shortness of breath, wheezing and coughing and help you carry out your daily activities more easily. 2 QUALITATIVE AND QUANTITATIVE COMPOSITION. This does not need emergency action as adrenal function is recovered in a few days, as verified by plasma cortisol measurements. It usually starts to work within a few minutes and the effects can last up to several hours. Patients should not rush stages 5, 6 and 7. The inhaler should be shaken immediately before releasing each puff. Possible systemic effects include Cushing's syndrome, Cushingoid features, adrenal suppression, decrease in bone mineral density, cataract and glaucoma and more rarely, a range of psychological or behavioural effects including psychomotor hyperactivity, sleep disorders, anxiety, depression or aggression (particularly in children) (see Paediatric population sub-heading below for information on the systemic effects of inhaled corticosteroids in children and adolescents). All products displayed on 1mg are procured from verified and licensed pharmacies. It is manufactured by Glaxo SmithKline Pharmaceuticals. Seretide MDI is available with or without a counter (see Section 4.2 Dose and Method of Administration). Childn ≥4 yr 1 inhalation of 50/100 bd. Fluticasone Propionate is a steroid. The increased incidence of reported pneumonia with Seretide 50/250 micrograms bd appears to be of similar magnitude to the incidence reported following treatment with Seretide 50/500 micrograms bd in TORCH. Got a health query? Single dose pharmacokinetic data have demonstrated that the systemic exposure to salmeterol and fluticasone propionate may be increased as much as two-fold when the AeroChamber Plus spacer device is used with Seretide inhaler as compared with the Volumatic spacer device. Possible systemic effects include Cushing's syndrome, Cushingoid features, adrenal suppression and growth retardation in children and adolescents (see section 4.4). The inhaler has been designed for use in a vertical position. Within the asthma cohort of 5362 first trimester ICS-exposed pregnancies, 131 diagnosed MCMs were identified; 1612 (30%) were exposed to FP or salmeterol-FP of which 42 diagnosed MCMs were identified. In a 3-year COPD study, older patients, patients with a lower body mass index (<25kg/m2) and patients with very severe disease (FEV1<30% predicted) were at greatest risk of developing pneumonia regardless of treatment. A clear benefit has not been shown as compared to inhaled fluticasone propionate alone used as initial maintenance therapy when one or two of the criteria of severity are missing. Seretide 250 Evohaler may be unsafe to use during pregnancy. GOAL showed more patients treated with Seretide achieved asthma control than patients treated with ICS alone and this control was attained at a lower corticosteroid dose. Patients should practise in front of a mirror for the first few times. This is equivalent to a delivered dose (ex actuator) of 21 micrograms of salmeterol and 44, 110 or 220 micrograms of fluticasone propionate. Buy SERETIDE 250 EVOHALER(GLAXOSMITHKLINE PHARMACEUTICALS LTD) with a composition(formula) of Fluticasone propionate 250 MCG+Salmeterol 25 MCG at MRP of RS 588.5999755859375. The counter will stop at 000 when all the recommended puffs have been used. Possible systemic effects include Cushing's syndrome, Cushingoid features, adrenal suppression, acute adrenal crisis and growth retardation in children and adolescents and more rarely, a range of psychological or behavioural effects including psychomotor hyperactivity, sleep disorders, anxiety, depression or aggression. This may lead to an increase in the incidence of systemic effects (e.g. The renal clearance of fluticasone propionate is negligible. Read more about it at : http://www.arohealth.com/copd/, Chronic pulmonary obstacle. Therapy should be down-titrated under physician supervision. All labs listed on the platform are accredited, 1mg uses Secure Sockets Layer (SSL) 128-bit encryption and is Payment Card Industry Data Security Standard (PCI DSS) compliant. This is equivalent to a delivered dose (ex actuator) of 21 micrograms of salmeterol and 44, 110 or 220 micrograms of fluticasone propionate. The lowest effective dose of fluticasone propionate needed to maintain adequate asthma control should be used in the treatment of pregnant women. Seretide 25 mcg+250 mcg (Inhaler) is a brand of the generic Salmeterol + Fluticasone Propionate. However, animal studies showed no effects of salmeterol or fluticasone propionate on fertility. It is important that patients start to breathe in as slowly as possible just before operating their inhaler. Seretide Evohaler 25 microgram/50 microgram per metered dose pressurised inhalation, suspension. 9. Any unused medicinal product or waste material should be disposed of in accordance with local requirements. Get contact details and address | ID: 20374476288 Each metered dose (ex valve) contains: 25 micrograms of salmeterol (as salmeterol xinafoate) and 250 micrograms of fluticasone propionate. Presenting symptoms are typically vague and may include anorexia, abdominal pain, weight loss, tiredness, headache, nausea, vomiting, hypotension, decreased level of consciousness, hypoglycaemia, and seizures. 4.8 Undesirable effects . This medicine is safe and effective. Cleaning (also detailed in patient information leaflet): Your inhaler should be cleaned at least once a week. 5. The safety and efficacy of Seretide inhaler in children aged under 4 years has not been established (see Section 5.1). Although there were no significant differences in the primary endpoint of the combined number of respiratory-related deaths and respiratory-related life-threatening experiences, the study showed a significant increase in asthma-related deaths in patients receiving salmeterol (13 deaths out of 13,176 patients treated with salmeterol versus 3 deaths out of 13,179 patients on placebo). By continuing to browse the site you are agreeing to our policy on the use of cookies. No difference in the risk of MCMs was identified following first trimester exposure to FP alone versus salmeterol-FP. This medicine is for inhalation only. Seretide 250 Evohaler is used to treat Asthma, Chronic obstructive pulmonary disorder (COPD). Please consult your doctor. Read about Seretide 250 Evohaler uses, side effects, dosage, price, composition and substitutes. Do not remove the canister from the plastic casing. ARD Pharma - Offering GSK Pharma Seretide 250mg Evohaler at Rs 540/bottle in Nagpur, Maharashtra. It is important, therefore, that the patient is reviewed regularly and the dose of inhaled corticosteroid is reduced to the lowest dose at which effective control of asthma is maintained. Therefore these patients should be treated with special care and adrenocortical function regularly monitored. What were the side-effects while using Seretide 250 Evohaler? The absolute bioavailability of a single dose of inhaled fluticasone propionate in healthy subjects varies between approximately 5 to 11% of the nominal dose depending on the inhalation device used. The primary objective of each study was to determine whether the addition of LABA to ICS therapy (salmeterol-FP) was non-inferior to ICS (FP) alone in terms of the risk of serious asthma related events (asthma-related hospitalisation, endotracheal intubation, and death). The combination should be avoided unless the benefit outweighs the increased risk of systemic glucocorticoid side effects. A decision must be made whether to discontinue breastfeeding or to discontinue Seretide therapy taking into account the benefit of breastfeeding for the child and the benefit of therapy for the woman. Systemic absorption of salmeterol and fluticasone propionate is largely through the lungs. Not all pack sizes may be marketed. A short-term trial of Seretide may be considered as initial maintenance therapy in adults or adolescents with moderate persistent asthma (defined as patients with daily symptoms, daily rescue use and moderate to severe airflow limitation) for whom rapid control of asthma is essential. SERETIDE EVOHALER 25/250 mikrog/annos inhalaatiosumute, suspensio 1 x 120 annosta. Ninety-nine percent (148/150) and ninety-five percent (142/150) of patients randomised to receive salmeterol-FP or FP alone, respectively, completed the double-blind period of the study. Seretide 250 Evohaler is used to treat Asthma, Chronic obstructive pulmonary disorder (COPD). 2. The counter cannot be reset and is permanently attached to the canister. Either the Volumatic or AeroChamber Plus spacer device can be used (depending on National Guidance). The benefits of inhaled fluticasone propionate therapy should minimise the need for oral steroids, but patients transferring from oral steroids may remain at risk of impaired adrenal reserve for a considerable time. Patients should consider getting a replacement when the counter shows the number 020. Inhalation aerosol. There are no data in humans. Once control of asthma is attained treatment should be reviewed and consideration given as to whether patients should be stepped down to an inhaled corticosteroid alone. The canisters are fitted into purple plastic actuators incorporating an atomising orifice and fitted with dustcaps. Seretide Inhaler. This may lead to an increase in the incidence of other systemic effects of salmeterol treatment (e.g. Before using for the first time patients should remove the mouthpiece cover by gently squeezing the sides of the cover, shake the inhaler well, hold the inhaler between the fingers and thumb with their thumb on the base, below the mouthpiece and release puffs into the air until the counter reads 120 to make sure that it works. Appropriate treatment should be promptly instituted, if indicated. Reporting suspected adverse reactions after authorisation of the medicinal product is important. 2. In general inhaled corticosteroids remain the first line treatment for most patients. Seretide 50/100 Diskus - One inhalation twice a day Seretide is not recommended for use in children below 4 years of age. 2. Seretide is steroid. For informational purposes only. Seretide Evohaler works as both a reliever and a preventer. Suffering cough and breathing problem, X ray has to be seen, and other blood reports too, I have a problem of cold from my childhood and asthma, Asthma needs assessment by pulmonary function tests and subsequent therapy depending on that, D PENICILLAMINE 125 TO 250 MG DAILY 50MG THRICE A DAY. Himalaya Wellness Tulasi Respiratory Wellness Syrup. Trẻ em từ 4 – 12 tuổi: Seretide Evohaler 25/50, xịt 2 cái/ 2 lần/ ngày. Seretide Evohaler 25 microgram /250 microgram per metered dose pressurised inhalation, suspension. It is less likely you have copd at this age You need detailed check up and spirometry test for same. Frequencies are defined as: very common (≥1/10), common (≥1/100 to <1/10), uncommon (≥1/1000 to <1/100), rare (≥1/10,000 to <1/1000) and not known (cannot be estimated from the available data). It is recommended that the height of children receiving prolonged treatment with inhaled corticosteroid is regularly monitored. The study showed that doubling the inhalations of each strength of Seretide for up to 14 days resulted in a small increase in βagonist-related adverse events (tremor; 1 patient [1%] vs 0, palpitations; 6 [3%] vs 1 [<1%], muscle cramps; 6[3%] vs 1 [<1%]) and a similar incidence of inhaled corticosteroid related adverse events (e.g. Co-treatment with other potent CYP3A inhibitors, such as itraconazole and cobicistat-containing products, and moderate CYP3A inhibitors, such as erythromycin, is also expected to increase the systemic fluticasone propionate exposure and the risk of systemic side effects. Concomitant treatment with ketoconazole or other potent CYP3A4 inhibitors should therefore be avoided unless the benefits outweigh the potentially increased risk of systemic side effects of salmeterol treatment (see section 4.5). Popularly searched for Seretide 250 Patients who have required high dose emergency corticosteroid therapy in the past may also be at risk. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. QUALITATIVE AND QUANTITATIVE COMPOSITION Each metered dose (ex valve) contains: 25 micrograms of salmeterol (as salmeterol xinafoate) and 50, 125 or 250 micrograms of fluticasone propionate. Salmeterol is a long-acting bronchodilator which works by relaxing the muscles in the airways and widens the airways. It is unknown whether salmeterol and fluticasone propionate/metabolites are excreted in human milk. 40,07 € Vain kirjautuneet asiakkaat voivat tilata tämän tuotteen. Replace the mouthpiece cover in the correct orientation. Pneumonia-related events were reported for 55 (7%) subjects in the Seretide 50/250 micrograms bd group and 25 (3%) in the salmeterol group. The dose of inhaled corticosteroid should be reduced to the lowest dose at which effective control of asthma is maintained. The tablet should not be swallowed. CLINICAL PARTICULARS . - Two inhalations of 25 micrograms salmeterol and 125 micrograms fluticasone propionate twice daily. For the full list of excipients, see section 6.1. Seretide Accuhaler 250/50 is a medicine containing the active ingredient(s) fluticasone propionate + salmeterol. 8. 2. The small increase in β agonist-related adverse events should be taken into account if doubling the dose of Seretide is considered by the physician in adult patients requiring additional short-term (up to 14 days) inhaled corticosteroid therapy. 2019] (online) Available from: Fluticasone propionate/formoterol fumarate dihydrate. itraconazole, telithromycin, ritonavir). Animal studies with salmeterol have shown embryofetal toxicity only at high exposure levels. Safety and efficacy of salmeterol-FP versus FP alone in asthma. 1mg provides you with medical information which is curated, written and verified by experts, accurate and trustworthy. [Accessed 18 Apr. Gargle with warm water after each inhalation to avoid any fungal infections in your mouth and throat. A multi-centre 8-week, double-blind, study was conducted to evaluate the safety and efficacy of salmeterol-FP metered dose inhaler (25/50 micrograms, 1 or 2 inhalations twice daily) versus FP (50 micrograms, 1 or 2 inhalations twice daily) alone in Japanese paediatric (6-month to 4 years of age) patients with infantile bronchial asthma. Active IngredientsAmoxicillin trihydrate, Potassium clavulanate. It relaxes the muscles of these airways. Both hoarseness and incidence of mouth and throat candidiasis may be relieved by rinsing the mouth with water and/or brushing the teeth after using the product. Patients should be instructed in the proper use of their inhaler (see patient information leaflet). The number will show through a window in the back of the plastic actuator. Other unidentified metabolites are also found in the faeces. Store it according to the instructions mentioned on the pack or label. The concomitant administration of ketoconazole should be avoided, unless the benefits outweigh the potentially increased risk of systemic side effects of salmeterol treatment. Seretide 250 Evohaler is used for Severe Allergic Reaction, Allergic Disorders, Asthma etc. There are no data available for use of Seretide in patients with hepatic impairment. Clinically significant effects were not seen on blood pressure, heart rate, blood glucose and blood potassium levels. Co-administration with erythromycin was not associated with any serious adverse effects. Repeat until you have inhaled the number of puffs as suggested by the doctor.Afterwards, rinse your mouth thoroughly with water and spit it out. Book any lab tests and preventive health packages from certified labs and get tested from the comfort of your home. It allows continued monitoring of the benefit/risk balance of the medicinal product. Seretide Accuhaler 250/50. Take the first dose of this medicine under medical supervision as it may cause wheezing or tightening of the airways (bronchospasm) immediately after using. Find affordable medicine substitutes, save up to 50% on health products, up to 80% off on lab tests and free doctor consultations. Re-titration to the lowest effective dose should always follow the introduction or change of a spacer device. Không dùng Seretide Evohaler cho trẻ em dưới 4 tuổi. Trẻ em từ 4 – 12 tuổi: Seretide Evohaler 25/50, xịt 2 cái/ 2 lần/ ngày. It is manufactured by GlaxoSmithKline. It allows you to live your life more freely without worrying so much about things that set off your symptoms. This medicine is used only for the maintenance treatment of … This medicine is used only for the maintenance treatment of asthma and is not useful for treating … An observational retrospective epidemiological cohort study utilising electronic health records from the United Kingdom was conducted to evaluate the risk of MCMs following first trimester exposure to inhaled FP alone and salmeterol-FP relative to non-FP containing ICS. 6.6 Special Precautions for Disposal There is likely to be a similar risk of interaction with other potent CYP3A4 inhibitors (e.g. 6. The symptoms may include wheezing, shortness of breath, and breathing difficulties. Dispose of the unused medicine. Use your rescue inhaler to control sudden difficulty in breathing. Patients should continue to use the same make of spacer device as switching between spacer devices can result in changes in the dose delivered to the lungs (see section 4.4). Do not stop using it unless you are advised to by your doctor. Concomitant use of other β adrenergic containing drugs can have a potentially additive effect. Uses Of SERETIDE 250MCG EVOHALER Uses Of Salt: Salmeterol. Get contact details and address | ID: 20374476288 Do not expose to temperatures higher than 50°C, protect from direct sunlight. SERETIDE EVOHALER inhalaatiosumute, suspensio 25/50 mikrog/annos, 25/125 mikrog/annos, 25/250 mikrog/annos Lataa äänitiedostona , MP3 (7,8 mt, 05.06.2018 19:09:36) Tulosta Know the uses, price, composition, substitutes, How it works for Seretide 250 Evohaler. Acute: Acute inhalation of fluticasone propionate doses in excess of those recommended may lead to temporary suppression of adrenal function. If symptoms are not getting relieved by the recommended doses, please consult the doctor for re-evaluation. Patients should be regularly reassessed by a doctor, so that the strength of Seretide they are receiving remains optimal and is only changed on medical advice. It works by stopping the release of certain chemical messengers that cause inflammation (swelling) of the airways. Start typing to retrieve search suggestions. - patients already adequately controlled on both inhaled corticosteroid and long-acting β2 agonist. Trẻ em dưới 4 tuổi. Children <12 years old may have difficulties synchronising aerosol actuation with inspiration of breath. Where the control of symptoms is maintained with the lowest strength of the combination given twice daily then the next step could include a test of inhaled corticosteroid alone. One pressurised canister delivers 120 actuations. • Do not stop taking Seretide or reduce the dose of Seretide without talking to your doctor first • Should be inhaled through the mouth into the lungs. Seretide Evohaler 25 microgram/250 microgram per metered dose pressurised inhalation, suspension. i m suffering from breathing problem cough chest infame . Patients should never try to alter the numbers on the counter or detach the counter from the metal canister. SERETIDE 25/50, 25/125, 25/250 INHALER Scheduling status: S4 Proprietary name (and dosage form): SERETIDE 25/50 INHALER SERETIDE 25/125 INHALER SERETIDE 25/250 INHALER Composition: Each single actuation of SERETIDE provides: Salmeterol xinafoate equivalent to 25 μg of salmeterol and 50, 125 or 250 μg of fluticasone propionate. No, do not stop taking Seretide 250 Evohaler. Potentially serious hypokalaemia may result from β2 agonist therapy. Reseptilääke SERETIDE EVOHALER 25/250 mikrog/annos inhalaatiosumute, suspensio 1 x 120 annosta. COPD Adult 1 inhalation of 50/250-50/500 mcg bd. Seretide 25 mcg+250 mcg (Inhaler) is a brand of the generic Salmeterol + Fluticasone Propionate. Cases of Cushing's syndrome and adrenal suppression have been reported. The canister contains a white to off white suspension. 2019] (online) Available from: MedlinePlus. SERETIDE Inhaler (with counter), 25 mcg/250 mcg, aerosol inhaler, metered dose. Patients should breathe out as far as is comfortable and then place the mouthpiece in their mouth between their teeth and close their lips around it. Seretide 250 Evohaler is a combination of two medicines that opens the airways and makes it easier to breathe. Patients should not be initiated on Seretide during an exacerbation, or if they have significantly worsening or acutely deteriorating asthma. During inhalation, the patient should preferably sit or stand. 40,07 € Vain kirjautuneet asiakkaat voivat tilata tämän tuotteen. In patients with asthma a lesser degree of systemic exposure to inhaled fluticasone propionate has been observed. CLINICAL PARTICULARS . In a trial which randomized children aged 4 to 11 years [n=428], salmeterol/fluticasone propionate Diskus (50/100 microgram, one inhalation twice daily) was compared with salmeterol/fluticasone propionate MDI (25/50 microgram, two inhalations twice daily) over a 12-week treatment period. This information is intended for use by health professionals. Information about this interaction is lacking for inhaled fluticasone propionate, but a marked increase in fluticasone propionate plasma levels is expected. For both studies, enrolled subjects had moderate to severe persistent asthma with history of asthma-related hospitalisation or asthma exacerbation in the previous year. Also view other alternatives Get free medicine home delivery in over 1000 cities across India. Medicine NameAugmentin 875/125mg Film Coated … On this page you will find out more about Seretide Accuhaler 250/50, including side effects, age restrictions, food interactions and whether the medicine is subsidised by the government on the pharmaceutical benefits scheme (PBS) Replace the inhaler when the counter reads 000. Hence, clinically significant drug interactions mediated by fluticasone propionate are unlikely. Medicine NameAugmentin 500mg/125mg Film-coated Tablets. Note: Seretide 25 microgram/50 microgram strength is not appropriate for adults and children with severe asthma. Seretide Evohaler 25/125, xịt 2 cái/ 2 lần/ ngày; Seretide Evohaler 25/250, xịt 2 cái/ 2 lần/ ngày. If so, your doctor may decide to reduce your dose to once a day. Combinations should be avoided unless the benefit outweighs the potential increased risk of systemic corticosteroid side-effects, in which case patients should be monitored for systemic corticosteroid side-effects. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Reseptilääke SERETIDE EVOHALER 25/250 mikrog/annos inhalaatiosumute, suspensio 1 x 120 annosta. The respective mechanisms of action of both drugs are discussed below. Seretide Evohaler Salmeterol/fluticasone propionate QUALITATIVE AND QUANTITATIVE COMPOSITION Each single actuation of Seretide provides: Salmeterol xinafoate equivalent to 25 micrograms of salmeterol and 50, 125 or 250 micrograms of fluticasone propionate. 25 micrograms of salmeterol (as salmeterol xinafoate) and 50, 125 or 250 micrograms of fluticasone propionate. Due to the fluticasone propionate component, hoarseness and candidiasis (thrush) of the mouth and throat and, rarely, of the oesophagus can occur in some patients. Seretide 250 Evohaler is a combination of two medicines that opens the airways and makes it easier to breathe. This does not require excessive force, the cover should click into position. Seretide Evohaler 25/125, xịt 2 cái/ 2 lần/ ngày; Seretide Evohaler 25/250, xịt 2 cái/ 2 lần/ ngày. Fluticasone Propionate is a steroid. Your doctor may regularly monitor your  blood potassium level as low oxygen level in the blood (hypoxia) and medicines such as Seretide 250 Evohaler can lower blood potassium level. Seretide 250 Evohaler, Packaging Size: 250/12 Gms, 250/12 Gms ₹ 400/ Pack Get Latest Price Composition : Salmeterol (25mcg) + Fluticasone Propionate (250mcg) In an interaction study in healthy subjects with intranasal fluticasone propionate, ritonavir (a highly potent cytochrome CYP3A4 inhibitor) 100 mg b.i.d. There is no incidence of additional adverse events following concurrent administration of the two compounds. The mean number of moderate to severe exacerbations per year was significantly reduced with Seretide as compared with treatment with salmeterol, FP and placebo (mean rate in the Seretide group 0.85 compared with 0.97 in the salmeterol group, 0.93 in the FP group and 1.13 in the placebo). Shake the inhaler. Read about company. Uses Seretide Evohaler is used for the treatment, control, prevention, & improvement of the following diseases, conditions and symptoms: Your privacy is guaranteed. While you are breathing in from mouth, press down on the inhaler one time to release the medication and hold your breath for 10 seconds.